METHOD AND COMPOSITION TO EVALUATE CYTOCHROME P450 2D6 ISOENZYME ACTIVITY USING A BREATH TEST

摘要

The present invention relates, generally to a method of determining andassessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity inan individual mammalian subject via a breath assay, by determining therelative amount of 13CO2 exhaled by a the subject upon intravenous or oraladministration of a 13C-labeled CYP2D6 substrate compound. The presentinvention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determinethe optimal dosage and timing of administration of CYP2D6 substrate compound.