2,2 ' and 6,6 ' - four substitution amino phosphine ligands and its synthetic method

摘要

This invention, 2,2 '' and 6,6 '' relates to the - four substitution amino phosphine ligands and its synthetic method. Skeletal structure of the ligand is shown on description below. This ligand, using 2,6 jinitorokurorobenzen this the coupling doing and as the starting raw materials, 2,2 '' and 6,6 '' the second step which obtains - tetra- amino biphenyl and, 2,2 '' and 6,6 '' reacting - tetra- amino biphenyl and phosphine halide 2,2 '' and 6,6 '' first step and 2,2 '' and 6,6 '' by adding hydrogen to - tetra- nitro biphenyl palladium/the carbon which obtain - tetra- nitro biphenyl under existing, 2,2 '' and 6,6 '' it is produced with the method of including with the third step which obtains - four substitution amino phosphine. The ligand itself of this invention akiraru is chemical compound, it is something whose synthetic method of that ligand is simple. This ligand is converted to the kiraru catalyst of bimetaru of single konhuigureshiyon by finally introducing kiraritei from outside. This ligand used the metal catalyst, it is used by the asymmetrical reaction of many types, possesses high reaction activity and stereoselectivity.