Method for forming intestinal adhesion of experimental animal, method for producing intestinal adhesion experimental animal, screening method for intestinal adhesion inhibitor, and intestinal adhesion inhibitor

摘要

The method for forming intestinal adhesion of an experimental animal of the present invention includes a cauterization step of cauterizing the intestinal tract of the experimental animal, and in the cauterization step, heat of a calorific value that induces the expression of IFN-γ in the intestinal tract of the experimental animal. give. Thereby, it is possible to provide a method for forming an intestinal tract adhesion in a laboratory animal that can form a desired degree of intestinal adhesion with high reproducibility. In addition, the intestinal adhesion inhibitor according to the present invention contains an IFN-γ inhibitor such as HGF, and is administered between 1 day before the operation in which the intestine is invaded and 30 minutes after the operation. Thereby, the intestinal adhesion inhibitor which can suppress intestinal adhesion can be provided.