METHOD FOR FORMATION OF INTESTINAL ADHESION IN EXPERIMENTAL ANIMAL, METHOD FOR PRODUCTION OF EXPERIMENTAL ANIMAL HAVING INTESTINAL ADHESION, METHOD FOR SCREENING OF INTESTINAL ADHESION-PREVENTING AGENT, AND INTESTINAL ADHESION-PREVENTING AGENT

摘要

Disclosed is a method for forming an intestinal adhesion in an experimental animal, which involves a cautery step for cauterizing the intestine in the experimental animal. In the cautery step, heat is applied to the intestine of the experimental animal in a quantity required for inducing the expression of IFN-γ. The method enables to form an intestinal adhesion to a desired extent with good reproducibility. Also disclosed is an agent for preventing the occurrence of an intestinal adhesion, which comprises an IFN-γ inhibitor such as HGF. The agent is administered within a period between 1 day before the operation of a surgery during which an intestine is invaded and 30 minutes after the surgery. The agent can prevent the occurrence of an intestinal adhesion.