Respect to the monomer of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers, and to provide a method of synthesis of both PNA oligomers of random-sequence PNA oligomers and the predetermined sequence present invention: wherein, R1, R2, R3, R4, R5 are independently, C 1 -C 4 alkyl, or halide of H, halogen, C l -C 4 alkyl, nitro, nitrile, C l -C 4 alkoxy, halogenated is a C 1 -C 4 alkoxy that is, there is a nitro one at least one of R5 and R1, R3,; are R6, a protected natural or unnatural H or α- amino acid side chain or the unprotected is; B is a nucleic acid base, natural or unnatural, and when said nucleobase has an exocyclic amino function, the functional group is unstable to acid base is weak to medium It is protected by a protecting group which is stable for. [Formula 1]
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