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Novel recombinant 15-kDa polypeptide and use of same in detecting human infection with Bartonella henselae

机译：新型重组15-kDa多肽及其在检测汉赛巴尔通体感染中的用途

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摘要

Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.

机译：公开了半裸巴尔通体的新型抗原的克隆和表达。发现重组多肽具有高度免疫原性，可用作诊断测试抗原。本发明的多肽提供了一种诊断测定的基础，该诊断测定可以使用患者的血清灵敏，快速，准确地诊断 Bartonella henselae 。还公开了针对IgG和IgM的ELISA，并允许诊断早期和晚期感染。

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公开/公告号US2010209936A1

专利类型
公开/公告日2010-08-19

原文格式PDF
申请/专利权人 JOHN G. HOEY;LISA P. HUANG;MARTIN E. ADELSON;ELI MORDECHAI;
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申请/专利号US20090462647
发明设计人 MARTIN E. ADELSON;ELI MORDECHAI;JOHN G. HOEY;LISA P. HUANG;
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申请日2009-08-06
分类号G01N33/53;C07K14/195;C07K17/00;C07H21/04;C12N15/63;C12N1/21;C12P21/02;
国家 US
入库时间 2022-08-21 18:55:53

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