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Mutants of Deoxycytidine Kinase Having Extended Enzymatic Activity
Mutants of Deoxycytidine Kinase Having Extended Enzymatic Activity
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机译:具有扩展的酶活性的脱氧胞苷激酶突变体
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摘要
The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
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