Process for the manufacture of 7-alpha-9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonylestra-1,3,5-(10)- triene-3,17-beta-diol

摘要

The present invention provides a novel multi-step process for the manufacturing Fulvestrant, which is economical and convenient to operate at commercial scale, and requires only simple chromatographic separations after the coupling step of adding the side chain to the 7 position of the steroid.