Synthesis of 17alpha-Acetoxyestra-1,3,5(10)-triene-3,11alpha-diol

摘要

Introduction of a hydroxy group into position 11 of natural estrogens and its subsequent modification often enhance biological activity of the initial steroid and endows it with new properties [1-3].11alpha-Hydroxy-estra-1,3,5(10)-trienes can also be used as synthons for the preparation of various 19-norsteroids [4];for example,compounds exhibiting antitumor activity were obtained on the basis of such 17alpha-ethynylestradiol analogs [5].