Compound, Pharmaceutical Composition and use of the compound in the manufacture of a Medicament for the treatment of Cognitive disorder related to or affected by the Histamine Receptor 3 (H3) and Process for the preparation of the compound

摘要

A compound used to treat central nervous system disorders associated with or affected by histamine-3 receptors. 1. Formula 1 compounds characterized by X1 as (cr4r5) P, Co or O; x2a and x2bson, each h or formed at the same time = O; m as 0; 1 or 2; n as 2; 3 or 4; P as 0; 1 or 2; Q as 1; 2 or 3; R1 and R2 as independent h, halogen or a group of tar or halide, each group of alternative; R3 is nr6r7, or a set of asphalt, cyclo armour, cyclo armour, cyclo armour, cyclo armour, cyclo armour or heterogeneous, each set of alternative conditionsWhen x2a and x2bse combine to form = O and P = 0, R3 is not quinoxalinil-2 (1H) - ona, or 1.3.4-oxadiazol; when x2a and x2b are h and P, R3 is not 1.2.4-triazol-5 (4h) - ona; R4 and R5 are independent h or a group of alternative bitumen or cyclopentadiene; R6 and R7 are independent h or a group of bitumen, alquenilo, alcoxi, cyclopentadiene, cyclopentadiene, cyclopentadienylEach optional substitution group or R6 and R7 of arilo or heteromorphism can form a 4-a7-selective substitution ring with the atoms attached to them, which can selectively contain one or two additional heteroatoms selected from n, The aromatic ring system of o o o o s or 9-A 15 can optionally be composed of two or three mixed or three substituted two or three ring aromatic ring members composed of extra heteroatoms selected from n or s, or a stereoheteroatom, Taurus or salt acceptable for drugs.