7 - piperazin acid amides of carboxylic acid - 2 - 1H indole inhibitors of p38 MAP Kinases, medicines containing them and Use thereof for the treatment of respiratory diseases.

摘要

That is proposed for the treatment of Diseases of the Airways in Asthma and COPD.Claim 1, characterized in that: compounds have the General formula (1) wherein R is a Substituent of the formula (2), (3) or (4), where R3 is C1 - C3 6 alkyl, cycloalkyl - 6, c1-4 alkoxy, Perfluoroalkyl C1 - 2, 3 - methyl - oxetan - 3 - ILO, perfluoroalcoxi c1-2, morfolinilo, where ra Dical cycloalkyl can be eventually replaced with c1-3 alkyl, wherein R4 is H,C1-4 alkyl, c1-4 alkoxy, wherein R5 C1 is H, alkyl sulfonyl amino - 5, - 6 cicloalquil C3 (alkyl sulfonyl Amine, 5 - C1 - (Methyl sulfonyl) amino) -, (cicloalquil C3 - 6 - - - (Methyl sulfonyl) amino) c1-5 alkyl carbonyl amino -, cicloalquil C3 - 6carbonil (C1 - amino - 5 - alkyl carbonyl) - (methyl) amino -, (C cicloalquil 3 - 6 - carbonyl) - (methyl) - amino alkyl aminocarbonilo, C1 - 5 - amino carbonylCicloalquil C3 - 6 - amino carbonyl, di - (c1-3 alkyl) - amino carbonyl, di - (c1-3 alkyl) amino - 2 - alkyl - C1, D - (c1-3 alkyl amino) - alkyl pyrrolidin-1-yl C1 - 2, 4 - C1 alkyl 5 - (piperazin-1-yl alkyl C1 - 2, 4 - Di - (c1-3 alkyl) amino - piperidin-1-yl alkyl C1 - 2, 3 - Di - (c1-3 alkyl) amino - piperidin-1-yl - alqui The c1-2, sulfinilo C15 alkyl -, 6 - sulfinilo cicloalquil C3, C1 - 5 - alkyl sulfonyl,Cicloalquil C3 - 6 - hydroxy alkyl sulfonyl, c1-2 alkyl, C1 - 5 - Methyl sulfinyl, c1-5 alkyl sulfonyl Methyl, wherein R6 is c1-3 alkyl or phenyl, alkyl radical where the C1 - 3 can be eventually replaced with Hydroxy alkyl - or di - (C1 3) - Amine and phenyl radical where the event can be Ualmente replaced with Fluorine or c1-3 alkyl, where D and e are Nitrogen, where G and E 'areIndependently of each other, nitrogen or Oxygen, wherein R6 is only attached to e when e is Nitrogen, R1 is a system containing cycloalkyl C4 - 6 1 2 nitrogen Atoms which may eventually be mono - or alkylated with R7, where R7 can be c1-3 alkyl, Hydroxy ALCO, XI c1-3 alkyl, amino, C1 - Di - (3 - amino, c1-3 alkyl) amino -, R2 is Hydrogen,C1-4 alkyl or Halogen; L - C or - N (H) , M - C or - N (H) , t is a link or alquileno c1-4, where radical alquileno c1-4 alkyl can be substituted with c1-2, M is 0, 1, 2, or 3, N is 1, 2 or 3, p is 0, 1, 2 or 3, where, if not mentioned otherwise, alqui groups The previously mentioned may be linear or branched chain, its tautomeros,Their stereoisomers, their mixtures and their salts, in particular their physiologically compatible Salts.