7- (Piperazin-1-ylmethyl) -1H-indole-2-carboxylic acid (phenyl) -amide derivatives and related compounds as MAP-QUINASA P38 inhibitors for the treatment of respiratory tract diseases.

摘要

Compounds of the general formula I ** Formula ** Ar means a substituent of the formula (II), (III) or (IV) wherein R3 means C1-6 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1 perfluoroalkyl -2,3-methyl-oxetan-3-yl, - C1-2 perfluoroalkoxy, morpholinyl, wherein the cycloalkyl radical may eventually be substituted with C1-3 alkyl, wherein R4 means H, C1-4 alkyl, C1- alkoxy 4, wherein R5 means H, C1-5-sulfonyl-amino, C3-6-cycloalkyl-amino, (C1-5-sulfonyl) - (methyl) -amino, (C3-6-sulfonyl cycloalkyl) - (methyl) -amino, C1-5 alkylcarbonyl amino, C3-6-cycloalkyl amino, - (C1-5 alkylcarbonyl) - (methyl) -amino, (C3-6-carbonylcycloalkyl) - ( methyl) -amino, aminocarbonyl, C1-5-alkyl-carbonyl alkyl, C3-6 -cycloalkylcarbonyl, di- (C1-3alkyl) -aminocarbonyl, di- (C1-3alkyl) -amino-alkyl C1-2, di- (C1-3 alkyl) -amino-pyrrolidin-1-yl-C1-2 alkyl, 4-alkyl C1-5-piperazin-1-ylalkylC1-2, - 4-di- (C1-alkyl) 3) -amino-piperidin-1-yl-C1- alkyl 2,3-di- (C1-3 alkyl) -amino-piperidin-1-yl-C1-2 alkyl, C1-5 alkyl sulfinyl, C3-6 cycloalkyl sulfinyl, C1-5 alkyl sulfonyl, C3 cycloalkyl 6-sulfonyl, hydroxy-C1-2 alkyl, C1-5 alkyl sulfinyl methyl, C1-5 alkyl sulfonyl methyl, wherein R6 means C1-3 alkyl or phenyl, - wherein the radical C1-3 alkyl can be optionally substituted with hydroxy or di- (C1-3 alkyl) -amino and where the phenyl radical may eventually be substituted with fluorine or C1-3.alkyl where D or E means nitrogen, where G and E 'mean, of independently of one another, nitrogen or oxygen, - where R6 is only attached to E 'when E' means nitrogen, R1 means a C4-6 cycloalkyl system containing 1 to 2 nitrogen atoms that may eventually be mono- or disubstituted with R7, wherein R7 can be C1-3 alkyl, hydroxy, C1-3 alkoxy, amino, C1-3 alkyl, di- (C1-3 alkyl) -amino.- R2 means hydrogen, halogen or C1-alkyl 4; L means -C (H) or -N , M means -C (H) or -N , T means a C1-4 alkylene or bond, wherein the C1-4 alkylene radical may be substituted with C1-2 alkyl, - m means 0, 1, 2 or 3, n means 1, 2 or 3 , p means 0, 1, 2 or 3, where, as long as nothing else has been mentioned, the aforementioned alkyl groups may be straight or branched chain, - their tautomers, their stereoisomers, their mixtures and their salts, in especially its physiologically compatible salts.