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use of polymer blends for the production of coated pharmaceutical formulations and mixed polymeric coated pharmaceutical formulations
use of polymer blends for the production of coated pharmaceutical formulations and mixed polymeric coated pharmaceutical formulations
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机译:聚合物共混物用于生产包衣药物制剂和混合的聚合物包衣药物制剂的用途
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摘要
The present invention relates to the use of a mixture of 2 to 60 wt% of one or more polymers (I) with 40 to 98 wt% of one or more polymers (II), wherein polymer (I) is a copolymer (meth) acrylate, containing 90 to 100 wt% polymerized with a 40 to 95 wt% radical of C1-4 alkyl esters of acrylic or methacrylic acid and 5 to 60 wt% of (meth) acrylate monomer units having a 10 wt.% anionic group of further polymerizable vinyl monomers and polymer (II) is a vinyl polymer other than polymer (I) or a polysaccharide or a polysaccharide derivative, containing 88 to 100% neutral monomer units and up to 12% by weight of ionic group polymerizable monomer units for the production of a coated pharmaceutical formulation containing an active agent core and a polymeric coating made from a mixture of polymers (I) and (II), characterized in that that the glass transition temperature of poly (I) is no more than 7000 and an active agent release profile is obtained, so agent release is retarded with respect to a pharmaceutical formulation with a coating made exclusively of polymer (I) starting at the same pH. . The invention further relates to a pharmaceutical formulation with a selected polymer (I).
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