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METHODS OF INDUCTION OF IMMUNE RESPONSE WITH THE APPLICATION OF DELIVERY OF NUCLEIC ACIDS, MEDIATED BY CATION LIPOSOMES

机译:阳离子脂质体介导的核酸传递诱导免疫反应的方法

摘要

The present invention relates to the field of drug delivery and, in particular, cationic liposome-based vaccines. In embodiments, the present invention provides methods for producing liposomes, the specificity of which is determined by a ligand (e.g., targeted by an antibody or antibody fragment), which can be used to deliver molecules to induce an immune response against viral antigens or to treat or prevent viral diseases. The specificity of the delivery system is determined by the ligands used.
机译:本发明涉及药物递送领域,尤其涉及基于阳离子脂质体的疫苗。在实施方案中,本发明提供了制备脂质体的方法,其特异性由配体(例如,被抗体或抗体片段靶向)确定,该配体可用于递送分子以诱导针对病毒抗原的免疫应答或针对治疗或预防病毒性疾病。递送系统的特异性由所使用的配体决定。

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