PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

摘要

Disclosed is a pyridine or pyrimidine derivative represented by the general formula (I), which has excellent inhibitory activity on HGFR and also has a potent cell growth inhibition effect and a potent anti-tumor effect on a cancer cell strain having the amplification of HGFR gene. (I) wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 independently represent a hydrogen atom; R4, R5, R6 and R7 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group or the like; R8 represents a hydrogen atom or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; and X represents a group represented by the formula:-CH= or a nitrogen atom.