PROCESS FOR THE PREPARATION OF HOMATROPINE AND ITS QUATERNARY SALTS THEREOF

摘要

The present invention provides a novel process for preparation of Homatropine bytrans-esterification reaction of tropine with DL-methyi mandelate in organic solvent using alkali metal alkoxide as catalyst in good yield and quality. Homatropine is then subjected to quartinisation to give its quartenary salt like Homatropine methyl bromide and Homatropine hydrobromlde.