Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors for chemosensitization or radiosensitization

摘要

Disclosed is a compound of formula (I), or an N-oxide form, addition salt, or stereoisomer thereof, wherein n is 0 or 1, s is 0 or 1, X is ûN= or ûCR4=, Y is ûN or ûCH, Q is ûNHû, ûOû, ûC(=O) û, ûCH2-CH2û, or ûCHR5û, R1 is C1-6alkyl or thienyl, R2 is hydrogen, and wherein the rest of the substituents are defined in the specification. Also disclosed is the use of the compounds as chemosensitization or radiosensitization agents for the treatement of cancer. Also disclosed is a process for making the compound.