Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells

摘要

A composition comprising (1) a means for inhibiting natural killer cell function, (2) non-ES, non EG, non-germ cells wherein the non-ES, non-EG, non-germ cells express one or more of telomerase, oct 3/4, rex-1, rox-1 or sox-2, and (3) a pharmaceutically acceptable carrier. Further disclosed is the use of the composition for the treatment of an adverse immune response caused by the non-ES, non EG, non-germ cells. The composition can be used to increase persistence and/or engraftment of MHC-I negative cells, such as multipotent adult progenitor cells (MAPCs).