Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of 13 cells in transgenic pigs

摘要

Dear Editor:Glucose-dependent insulinotropic polypeptide（GIP）and proglucagon product glucagon-like peptide-1（GLP-1）and their corresponding receptors promote secretion of glucose-dependent insulin[1]and may be responsible for up to 70%of postprandial insulin secretions[2].A diminished incretin effect is typical for type 2 diabetes mellitus（T2DM）patients and their normoglycemic first-