The present invention relates to compounds of formula (I) wherein R1is hydrogen, lower alkyl or benzyl which may be optionally substituted by halogenor lower alkoxy; R2 is hydrogen, halogen or OR, wherein R is lower alkyl,aryl or lower alkyl substituted by halogen; R3 is hydrogen or fluorine;Ar is phenyl; n is 0 or 1; o is 0, 1 or 2; and to their pharmaceutically active salts.It has been found that the compounds of formula I have a good affinity to the traceamine associated receptors (TAARs), especially for TAAR1. The compounds maybe used for the treatment of depression, anxiety disorders, bipolar disorder,attention deficit hyperactivity disorder (ADHD), stress-related disorders,psychotic disorders such as schizophrenia, neurological diseases such as Parkinson'sdisease, neurodegenerative disorders such as Alzheimer's disease, epilepsy,migraine, hypertension, substance abuse and metabolic disorders such as eatingdisorders, diabetes, diabetic complications, obesity, dyslipidemia, disordersof energy consumption and assimilation, disorders and malfunction of body temperaturehomeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
展开▼