NEW PROCEDURE FOR THE SYNTHESIS OF DERIVATIVES OF 1,3,4,5-TETRAHIDRO-2H-BENZACEPI-2-ONA AND ITS APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALES OF ACID.

摘要

Synthesis process of the compounds of formula (I): ** (See formula) ** in which R1 and R2, identical or different, each represent a linear or branched (C1-C8) alkoxy group, or together form with the carbon atom that carries them, a 1,3-dioxane, 1,3-dioxolane or 1,3 dioxepane cycle. characterized in that the compound of formula (VI): ** (See formula) ** in which R1 and R2 are as defined above, is subjected to a catalytic hydrogenation reaction in a non-acid solvent, then filtered the reactive medium, to lead to the compound of formula (I).