Micro-reactor synthesis: synthesis of cyanobiphenyls using a modified suzuki coupling of an aryl halide and aryl boronic acid.

摘要

The synthesis of cyanobiphenyls using a modified Suzuki copuling was performed in a micro-reactor system (channel geometries of 300 #mu# m wide and 115 #mu# m deep) etched in borosilicate glass, using a photolithographic patterning technique~([1]). The organic starting reagents were moved by electro-osmotic flow (EOF). A micro-porous silica structure~([2]) was used within the channels, to act as a micro-ump and also assist in the immobilisation process for the heterogeneous catalyst bed.