PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY

摘要

The present invention relates to compounds of the formula (1)and thepharmaceutically acceptable forms thereof; wherein X, Y, a, b, c. d, R1, R2,R3, R4 and R5 are as defined herein. Moreover, the present invention is alsodirected at pharmaceutical compositions comprising a compound of the formula Iand a pharmaceutically acceptable carrier. Furthermore, the present inventionis directed at methods of using the herein described compounds andcompositions for treating or preventing a disorder or condition that can betreated or prevented by antagonizing the 15 CCR1 receptor in a mammal.