USE OF GINSENOSIDE RB1 IN PREPARING MEDICAMENTS FOR TREATING DILATED CARDIOMYOPATHY

摘要

Use of ginsenoside Rb1 in preparing medicaments for treating dilated cardiomyopathy is provided. After long-term treatment, ginsenoside Rb1 can decrease mortality of dilated cardiomyopathy, improve cardiac function, lessen left ventricular dilatation, attenuate hypertrophy of cardiomyocytes and proliferation of interstitial collagen, reduce irregular width and disorderly arrangement of myocardial fibres, mitochondrial swelling, break of crista, dilated sarcoplasmic reticulum, breakdown of intercellar junction, increase expression of cardiac gap junction protein Cx40, E-cadherin, P- cadherin, fibroblast growth factor FGF2, FGF7, FGF8, FGF10, and reduce expression of integrin Itga8, Itgbp.