MEDICAMENTS CONTAINING BENZOQUINONE- OR CONDENSED PYRIMIDINE DERIVATIVES AS ACTIVE INGREDIENT FOR TREATING OF MYOCARDITIS, DILATED CARDIOMYOPATHY AND CARDIAC INSUFFICIENCY

摘要

The present invention relates to pharmaceutical compounds for the treatment and prevention of myocarditis, dilated cardiomyopathy and heart failure containing an NF-κB inhibitor as an active ingredient. The NF-κB inhibitor is a benzoquinone derivative of the Formula I, a hydroquinone form thereof, or a pharmaceutically acceptable salt thereof, wherein R 1, R 2 and R 3 are independently hydrogen, alkyl or alkoxy; R4 is hydrogen, hydroxymethyl, alkyl or an optionally esterified or amidated carboxyl group; Z is a substituted benzene ring; and n is an integer from 0 to 6. The NF-κB inhibitor may also be an indan derivative of formula (XVII), or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; and R2 is hydrogen, ether, ester, carboxyl, amide or alkenyl; the pyrimidine-fused portion is a heterocyclic ring. SHE