FK506 AND FK520 ANALOGUES AND THEIR PHARMACEUTICAL USES

摘要

The present invention relates to novel FK506 and FK520 analogues and strains generated by replacing the natural loading module of the FK506 or FK520 polyketide synthase (PKS) with the avermectin or an avermectin-like PKS loading module and optionally feeding non-natural starter units to these strains and to use of such compounds in therapy.