SINGLE NUCLEOTIDE POLYMORPHISM MARKER OF HSD11B1 ALLELE FOR PREDICTION AND DIAGNOSIS OF RISK IN OSTEOPOROSIS AND OSTEOPOROTIC COMPRESSION

摘要

PURPOSE: A HSD11B1 polymorphysm marker for predicting and diagnosing osteoporosis and osteoporotic fracture is provided to develop a kit for predicting and diagnosing osteroporosis. CONSTITUTION: A HSD11B1 polymorphism marker is used for predicting and diagnosing osteoporosis and osteroporotic fracture. The polymorphism marker has polymorphism of -19835GA, +16374GA, +27447GC or haplotype thereof. A method or predicting and diagnosing risk of osteoporosis and osteoporotic fracture comprises: a step of detecting polymorphic site of HSD11B1 gene from DNA extracted from a sample; and a step of analyzing relation between detected polymorphic site and osteoporosis phenotype change. A kit for predicting and diagnosing osteoporosis and osteoporotic fracture contains a primer set which amplifies polymorphic site of HSD11B1 gene, molecular weight marker, amplifying enzyme, nucleotide, and buffer.