RECOMBINANT ADENOVIRUS FOR PREVENTING AND TREATING FOOT-AND-MOUTH DISEASES, EXPRESSING siRNA HAVING AN EFFECT OF SUPPRESSING FOOT-AND-MOUTH VIRUS PROLIFERATION

摘要

PURPOSE: A recombinant adenovirus expressing siRNA for suppressing and preventing foot-and-mouth virus is provided to generate siRNA targeting foot-and-mouth virus 2B and 3C genes and to ensure antiviral effect.;CONSTITUTION: A recombinant adenovirus comprises a nucleotide of sequence number 3 or 5 and complementary nucleotide thereof(sequence number 4 or 6). An siRNA which specifically binds to the foot-and-mouth virus is synthesized from a DNA having a nucleotide of sequence number 1 or 2, or complementary nucleotide thereof. An antiviral formulation for foot-and-mouth contains the recombinant adenovirus expressing siRNA as an active ingredient.;COPYRIGHT KIPO 2010