Recombinant adenovirus expressing small interference RNA to inhibit foot-and-mouth disease virus

摘要

The present invention is a recombinant adenovirus expressing siRNA specifically designed for the purpose of suppression and prevention of foot-and-mouth disease virus relates to a virus . More particularly, the foot-and-mouth disease virus who state occurs in our country (O / SKR / 2002) of searching for specific base sequence , and then cloned into a recombinant adenovirus was prepared by cloning adenovirus vector design , based on this, the non-structural protein region of the nucleotide sequence relates to a virus , by applying it before the animal is infected with a virus , the virus shows a suppressing effect , even if applied after an animal is infected with the virus indicated the proliferation inhibitory effect of the virus can be utilized in both the prevention and treatment of foot-and-mouth disease .