A novel peptide for increasing the protein expression of Brain-derived neurotrophic factor in the hippocampal neuronal cell, the hippocampal tissue and the cerebral cortex tissue

摘要

The present invention relates to a novel peptide that increases the protein expression of BDNF (Brain-derived neurotrophic factor) . In particular, the present invention as the hippocampus and cerebral cortex neurons by increasing the expression of BDNF mRNA and protein in the tissue of Alzheimer's disease, Parkinson's disease, depression, stroke, Huntington's chorea, cerebral ischemic diseases, neurodegenerative diseases, or diabetic neuropathy, etc. It provides novel peptide can be used as a preventive or therapeutic agent for diseases. A three amino acids of the present invention MVG (Methionine-Valine-Glycine) peptide learning and memory, hippocampal the mRNA and protein expression of key features, such as protecting the material of BDNF, anti-depression of the dopamine neurons neurons, hippocampal tissue and It increased in the cerebral cortex tissue.