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Mitoquinone derivatives used as mitochondrially targeted antioxidants, a method of preparing the same and a pharmaceutical composition comprising the same
Mitoquinone derivatives used as mitochondrially targeted antioxidants, a method of preparing the same and a pharmaceutical composition comprising the same
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机译:用作线粒体靶向抗氧化剂的线粒体醌衍生物,其制备方法和包含其的药物组合物
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摘要
This invention relates to methods to screen for, identify, select and synthesise amphiphilic mitochondrially targeted antioxidant compounds, and compositions, dosage forms and methods reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.
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