INDOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR INHIBITORS FOR TREATMENT OF COGNITIVE DISORDERS AND DISORDERS OF SLEEP, OBESITY AND OTHER DISORDERS OF THE CENTRAL NERVOUS SYSTEM

摘要

1. The compound of the formula:! ! in which the spacer is! ! Y represents CH or N, provided that if Y represents CH, then n is 0-2; if Y is N, then n is 2-4; ! if Y is CH, then R1 and R2, taken together, are - (CH2) a-NR11- (CH2) 2-, where a is 1-2, which together with Y forms a piperidine or pyrrolidine ring, which is optional substituted by 1-3 groups selected from a fluorine atom, fluoroalkyl, (C1-C4) alkyl, alkoxyl, aryl, (C3-C7) cycloalkyl, heterocycloalkyl groups containing 1-2 heteroatoms selected from (O, S) and ( C1-C5) alkyl-O- (C1-C5) alkyl; and! if Y is N, then R1 and R2 independently represent a (C1-C5) alkyl or (C3-C6) cycloalkyl group, or R1 and R2 taken together with the nitrogen atom to which they are attached form a 5-7 membered heterocyclic a ring system with 0-1 additional heteroatom selected from O and S, which is optionally substituted with 1-3 (C1-C5) alkyl, fluoroalkyl or (C3-C6) cycloalkyl groups, or R1 and R2, taken together, are - (CH2) a-NR11- (CH2) 2-, where a is 2-3, which together with Y forms a piperazine or homopiperazine ring, which, neo optionally substituted by 1-3 groups selected from a fluorine atom, fluoroalkyl, (C1-C4) alkyl, alkoxy, aryl, (C3-C7) cycloalkyl, heterocycloalkyl group containing 1-2 heteroatoms selected from (O, S), and (C1-C5) alkyl-O- (C1-C5) alkyl; ! R3 represents 0-2 groups selected from a halogen atom, (C1-C6) alkyl, (C1-C6) alkoxyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkyl- (C1-C6) alkyl, heterocycloalkyl groups containing 1-3 heteroatoms selected from (O, S) and (C1-C3) alkyl-O- (C1-C5) alkyl�