where a spacer represents Y represents N; R1 and R2 together with nitrogen atom whereto attached form a 5-6-members heterocyclic ring system which is optionally substituted by 1-3 (C1-C5)alkyl groups; n is equal to 2-4; R represents 0-2 groups selected from halogen atom, (C1-C6)alkyl, (C1-C6)alkoxy groups; R4 and R5 are independently selected from H, (C1-C5)alkyl, (C1-C8)alkoxy groups, halogen atom; R6 represents H, CONR7R8, -(CH2)x-O-R9, (C1-C4)alkyl group, COOC2H5, cyclopropyl; x is equal to 1-4; R7 and R8 independently represent hydrogen, (C1-C5)alkyl group, (C3-C7)-cycloalkyl group, -CH2-cyclohexyl, or R7 and R8 together with nitrogen atom whereto attached form a 5-6-members heterocyclic ring system with 0-1 additional heteroatom selected from O; R9 represents hydrogen, (C1-C5)alkyl, (C3-C7)cycloalkyl group; and its pharmaceutically acceptable salt, and its individual stereoisomers.;EFFECT: compounds inhibit histamine H3-receptor that allows to use them for preparing pharmaceutical compositions.;6 cl, 10 dwg, 1 tbl, 44 ex"/>
INDOLE DERIVATIVES AS HISTAMINE H3-RECEPTOR INHIBITORS FOR TREATING COGNITIVE DISORDERS AND SLEEP DISTURBANCES, OBESITY AND OTHER DISORDERS OF CENTRAL NERVOUS SYSTEM
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INDOLE DERIVATIVES AS HISTAMINE H3-RECEPTOR INHIBITORS FOR TREATING COGNITIVE DISORDERS AND SLEEP DISTURBANCES, OBESITY AND OTHER DISORDERS OF CENTRAL NERVOUS SYSTEM
INDOLE DERIVATIVES AS HISTAMINE H3-RECEPTOR INHIBITORS FOR TREATING COGNITIVE DISORDERS AND SLEEP DISTURBANCES, OBESITY AND OTHER DISORDERS OF CENTRAL NERVOUS SYSTEM
FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to compounds of formula: where a spacer represents Y represents N; R1 and R2 together with nitrogen atom whereto attached form a 5-6-members heterocyclic ring system which is optionally substituted by 1-3 (C1-C5)alkyl groups; n is equal to 2-4; R represents 0-2 groups selected from halogen atom, (C1-C6)alkyl, (C1-C6)alkoxy groups; R4 and R5 are independently selected from H, (C1-C5)alkyl, (C1-C8)alkoxy groups, halogen atom; R6 represents H, CONR7R8, -(CH2)x-O-R9, (C1-C4)alkyl group, COOC2H5, cyclopropyl; x is equal to 1-4; R7 and R8 independently represent hydrogen, (C1-C5)alkyl group, (C3-C7)-cycloalkyl group, -CH2-cyclohexyl, or R7 and R8 together with nitrogen atom whereto attached form a 5-6-members heterocyclic ring system with 0-1 additional heteroatom selected from O; R9 represents hydrogen, (C1-C5)alkyl, (C3-C7)cycloalkyl group; and its pharmaceutically acceptable salt, and its individual stereoisomers.;EFFECT: compounds inhibit histamine H3-receptor that allows to use them for preparing pharmaceutical compositions.;6 cl, 10 dwg, 1 tbl, 44 ex
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