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COMPOSITIONS WITH CYTOKINE MODULATING PROPERTIES

机译:具有细胞因子调节特性的组合物

摘要

1. A method of modulating one or more immunoregulatory cytokines, comprising administering to a subject a therapeutically effective amount of one or more phosphate derivatives of one or more hydroxychromanes or their complexes. ! 2. The method according to claim 1, in which the immunoregulatory cytokine is an inflammatory cytokine or anti-inflammatory cytokine. ! 3. The method according to claim 2, in which the inflammatory cytokine is a cytokine type of interleukin or a cytokine type of tumor necrosis factor. ! 4. The method according to claim 3, in which the cytokine type interleukin is selected from the group consisting of interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 ( IL-8), interleukin-11 (IL-11) and interleukin-18 (IL-18). ! 5. The method according to claim 3, in which the cytokine type of tumor necrosis factor is a tumor necrosis factor-alpha. ! 6. The method of claim 2, wherein the anti-inflammatory cytokine is an interleukin type cytokine, tumor necrosis factor type cytokine, interferon cytokine or growth factor cytokine. ! 7. The method according to claim 6, in which the cytokine type of interleukin is selected from the group consisting of interleukin-4 (IL-4), interleukin-10 (IL-10) and interleukin-13 (IL-13). ! 8. The method according to claim 6, in which the cytokine-interferon is an IFNα. ! 9. The method according to claim 6, in which the cytokine growth factor is a transforming growth factor or colony stimulating factor granulocytes. ! 10. The method according to claim 6, in which the transforming growth factor is TGFβ. ! 11. The method according to claim 6, in which the colony-stimulating factor of granulocytes is G-CSF. ! 12. The method according to claim 1, in which the phosphate derivative of hydroxychroman is selected from
机译:1.一种调节一种或多种免疫调节细胞因子的方法,其包括向受试者施用治疗有效量的一种或多种羟基苯甲醚或其复合物的一种或多种磷酸酯衍生物。 ! 2.根据权利要求1的方法,其中所述免疫调节细胞因子是炎性细胞因子或抗炎细胞因子。 ! 3.根据权利要求2的方法,其中所述炎性细胞因子是白介素的细胞因子类型或肿瘤坏死因子的细胞因子类型。 ! 4.根据权利要求3的方法,其中所述细胞因子类型白介素选自白介素-1α(IL-1α),白介素-1β(IL-1β),白介素-6(IL-6),白介素-8(IL-8),白介素11(IL-11)和白介素18(IL-18)。 ! 5.根据权利要求3所述的方法,其中所述肿瘤坏死因子的细胞因子类型是肿瘤坏死因子-α。 ! 6.权利要求2的方法,其中所述抗炎细胞因子是白介素型细胞因子,肿瘤坏死因子型细胞因子,干扰素细胞因子或生长因子细胞因子。 ! 7.根据权利要求6的方法,其中白介素的细胞因子类型选自白介素4(IL-4),白介素10(IL-10)和白介素13(IL-13)。 ! 8.根据权利要求6的方法,其中所述细胞因子-干扰素是IFNα。 ! 9.根据权利要求6的方法,其中所述细胞因子生长因子是转化生长因子或集落刺激因子粒细胞。 ! 10.根据权利要求6的方法,其中转化生长因子是TGFβ。 ! 11.根据权利要求6的方法,其中粒细胞的集落刺激因子是G-CSF。 ! 12.根据权利要求1的方法,其中羟基苯并二氢吡喃的磷酸盐衍生物选自

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