IMPLANTED NEURO-ENDOPROSTHESIS SYSTEM, METHOD FOR ITS OBTAINING AND METHOD FOR CARRYING OUT A RECONSTRUCTIVE NEUROSURGICAL OPERATION

摘要

1. An implantable neuroendoprosthetic system for replacing defects in the brain and spinal cord and the autonomic nervous system of a mammal during reconstructive neurosurgical operations, which is an elastically elastic cell-biopolymer biologically active mass obtained from a heterogeneous collagen-containing matrix for implantation and biocomposition of autologous patient cells from various cell types of cell preparations from various cell preparations. ! 2. The implantable system according to claim 1, characterized in that the biocomposition contains in the NaCl solution neural stem cells (NSC), neuroglial parietal cells (NGOK), endothelial cells with a marker CD34 + (EC) and purified mononuclear cells (MN) in the following ratio components (in parts by the number of cells): NSC - 0.8-1.2; NGOK - 1.6-2.4; EC - 4-6; MN - 4000-6000. ! 3. The implantable system according to claim 2, characterized in that a 0.5-1.3% NaCl solution is used. ! 4. The implantable system according to claim 1, characterized in that the composition of the heterogeneous implantable gel "Sphero® GEL" is used as a heterogeneous collagen-containing matrix. ! 5. The implantable system according to any one of claims 1 to 4, characterized in that it contains the following number of cells in 0.5-1 ml of 0.9% NaCl solution based on 1 ml of heterogeneous collagen-containing matrix: NSC - 106; NGOK - 2 · 106; EC - 5 · 106; MH -5109. ! 6. The implantable system according to claim 1, characterized in that the biocomposition further comprises stimulators of cell regeneration and growth factors of nerves and blood vessels. ! 7. A method of obtaining an implantable neuroendoprosthetic system for replacing defects in the brain and spinal cord and the autonomic nervous system of a mammalian