CHEMOENZYMATIC METHOD FOR SYNTHESIS OF STATIN AND STATIN INTERMEDIATE

摘要

PPROBLEM TO BE SOLVED: To provide methods for making statin, such as atorvastatin (LIPITOR (R)), rosuvastatin (CRESTOR (R)), fluvastatin (LESCOL (R)), related compounds, and their intermediates. PSOLUTION: The invention provides novel aldolases, nucleic acids encoding them, e.g., nucleic acids of a gene sequence comprising a specific sequence, or a polypeptide comprising an amino acid sequence of a specific sequence or an enzymatically active fragment thereof, and uses of them. PCOPYRIGHT: (C)2011,JPO&INPIT