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SYNTHESIS OF RING B ABEO-STEROLS AS NOVEL INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS

机译：新型环状抑制剂结核分枝杆菌环丁烯二酚的合成

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摘要

Novel 3β-hydroxy-Δ⁵-steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis. The 5(6→7)abeo-sterol nucleus present in compounds of the invention represents a novel scaffold for the development of new antitubercular agents.

机译：具有收缩的环戊烷B环的新型3β-羟基-Δ^{5 -类固醇类似物具有良好的对结核分枝杆菌的抑制活性。存在于本发明化合物中的5（6→7）abeo-甾醇核代表了用于开发新的抗结核剂的新型支架。} 展开▼

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公开/公告号US2011087037A1

专利类型

公开/公告日2011-04-14

原文格式PDF

申请/专利权人 ABIMAEL D. RODRIGUEZ-PIERLUISSI;XIAOMEI WEI;
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申请/专利号US20080740901

发明设计人 ABIMAEL D. RODRIGUEZ-PIERLUISSI;XIAOMEI WEI;
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申请日2008-10-31

分类号C07J9/00;

国家 US

入库时间 2022-08-21 18:15:21

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