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USE OF EPICATECHIN AND DERIVATIVES AND SALTS THEREOF FOR CARDIAC PROTECTION OF ISCHEMIC MYOCARDIUM AND TO AMELIORATE ADVERSE CARDIAC REMODELING
USE OF EPICATECHIN AND DERIVATIVES AND SALTS THEREOF FOR CARDIAC PROTECTION OF ISCHEMIC MYOCARDIUM AND TO AMELIORATE ADVERSE CARDIAC REMODELING
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机译:EPICATECHIN及其衍生物和盐用于心脏保护缺血性心肌和减轻不良心脏重塑
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摘要
The disclosure provides a method of reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof, wherein the subject is a human or a veterinary animal. Additionally the disclosure provides a method of treating subarachnoid hemorrhage or atrial fibrillation or of enhancing or preserving migration, seeding, proliferation, differentiation and/or survival of stem cells in injured heart tissue comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof. The effects of epicatechin administration are sustained over time.
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