"/> Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine
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Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine

机译:增强AMPA受体的化合物及其在医学中的用途

摘要

Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, N and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.;
机译:提供了式(I)的化合物及其盐:其中n为0、1、2或3;和R Sup 1选自苯基和吡啶基,它们各自任选地被一个或两个独立地选自C 1-4烷基和卤素的基团取代;当n为1时,选自H和CH 3 ;当n为2或3时,选自R 2 为H。还公开了药物组合物,N及其作为药物的用途,例如用于治疗由谷氨酸受体功能的降低或失衡介导的疾病或病症,例如精神分裂症或认知障碍。

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