Allosteric Modulators of the A1 Adenosine Receptor

摘要

The present invention provides compounds of formula (I); ;wherein R₁, R₂, R₃, R₄ and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the A₁ adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A_l adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain; cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke; neurological disease or injury; sleep disorder; epilepsy; and depression.