Prevention and Treatment of cancer with Ras gene mutation. Pharmaceutical composition. Use.

摘要

Claim 1: a method for treating or Preventing cancer with Ras Gene Mutation in a Mammal in need thereof, wherein the method comprises administering to the Mammal an effective amount of at least one of the compound 1, a Salt thereof or a prodrug thereof,Where 1 is the compound represented by the formula (1) where W is C (R1) or N; is an aryl group or an optionally substituted heteroaryl Group optionally substituted; X1 - Y1 - NR1 -, - O -, - S -, - and - SO2 -, - or - chr3 -Where R is a hydrogen Atom or a Hydrocarbon Group optionally substituted aliphatic or R3 is optionally linked to a C Atom or a heteroatom in the aryl or heteroaryl Group represented by the group to form a cyclic Structure replaced optionallyAnd Y1 is a link or a c1-4 alquileno replaced optionally or - or - (alquileno c1-4) replaced Optionally, R1 is an H Atom or group replaced optionally linked Via A C Atom, N Atom or Atom, orAnd R2 is H Atom or group replaced optionally linked Via A C Atom or Atom s or R1 and R2 and R2 and R3 are connected to form a cyclic Structure optionally optionally substituted compounds are excluded, provided that representatives of the f Ormulas (2).Claim 1: a Pharmaceutical composition for treating or Preventing cancer with Ras Gene Mutation in a Mammal in need thereof, characterized in that it comprises N - {2 - [4 - ({3 - Chloro - 4 - [3 - (trifluoromethyl) phenoxy] phenyl] amino) - 5h pyrrolo [3,2-d] pyrimidin-5-yl) ethyl] - 3 - hydroxy - 3 - metilbutan Amide, a Salt of the same or a prodrug of the same in a therapeutically effective amount.Claim 1: Use of N - (2 - [4 - ({3 - Chloro - 4 - [3 - (trifluoromethyl) phenoxy] phenyl] amino) - 5h pyrrolo [3,2-d] pyrimidin-5-yl) ethyl] - 3 - hydroxy - 3 - metilbutanamida, a Salt of the same or a prodrug thereof for preparing a Pharmaceutical composition for treating or Preventing cancer with mutation Ras Gene in a Mammal in need thereof.