Use of a quinolone derivative containing a Group 7 - (4 - Aminomethyl - 3 oxime) pyrrolidine is able to induce granulocyte colony-stimulating factor for the treatment of neutropenia and the Recovery of hematopoiesis

摘要

An antibiotic compound of pentachlorophenol, which can promote the production of G-CSF in vivo and neutron openia therapy, as well as the early recovery of immune inoculation as an active component. Item 1: a drug for the treatment of neutron openia, which contains an effective treatment quantity represented by the formula (1),A pharmaceutically acceptable dissolved salt, including hydrate, ester, isocyanate or isocyanate, wherein R represents hydrogen, methyl or amine, Q represents C-H, C-F, C-Cl, c-oh, c-ch3, c-o-ch3 or N, R1 represents hydrogen, cyclopentane, methyl or ethyl, or phenyl, and is replaced by one or more fluorine atoms, R2 represents one of (a) to (E): (a) hydrocarbon, C1-C4 rectum or resin, cycloacrylonitrile, cyclopropylmethyl, acrylonitrile C3-6, 2- haloethyl ester, methoxy, methoxymethanol, phenyl or propylene; (b) a group of formulations (2), wherein X represents hydrogen, 2-.3-o4-fluorine, cyanogen, nitric acid, thyroid, C1-4 hydrocarbon or 2.4-fluorine, c) one of the following formulas (3);(d) A set of the following formulas (4);(e) A group of the following formulas (5), n for 0 or 1, m for 0, 1 or 2; X for methylene, O or N, R3 for - ch2nr5r6, wherein R5 and R6 independently represent c1-3 or R5 and R6 hydrogen or hydrocarbon, together with the nitrogen atom connected with them, can form a ring, R4 stands for hydrogen, or R3 and R4, plus the carbon atoms connected to them, stands for a formula structure (6) combining a helical pyridine ring, where R7 stands for C1-4 hydrogen or tar. Second requirement: drugs according to the first requirement,Its characteristic is that the formula compound (1) is gem amide. Item 6: drug according to Item 1 or item 2, which is characterized by neutron surgery to induce cancer patients to receive non chemotherapeutic polio treatment. Item 7: the drug meets the requirements of item 6, which is characterized by non chemotherapy myelosuppression therapy selected from gancicvir, acclovir, valaciclovir, valganciclovir, pencelovir, famciclovir, vidabina, citanabina, idosukuridina, trifluridina, edoxana, brivudina. Item 20: drugs provided in accordance with item 11,Hematological reconstruction is characterized by (a) or (b) the addition of a formula compound (1) to a medium containing a mixture of citoquin and growth factor to culture a group of cells, including blood stem cells, Therefore, increasing the innate bone marrow cells in the cell group, and (b) a method of adding a formula compound (1) to an appropriate pharmaceutical environment for the management of mammalian hosts and the reactivation of the innate bone marrow cells.