immunogenic composition, vaccine, pharmaceutical composition, fusion polypeptide and use of the first three

摘要

IMMUNOGENIC COMPOSITION, VACCINE, PHARMACEUTICAL COMPOSITION, Fusion Polypeptide and Use of the First Three. The present invention relates to an immunogenic composition, vaccine or pharmaceutical composition for the prevention, reinforcement or treatment of infection caused by a species of the tuberculosis complex (M. tuberculosis, M. bovis, M. africanum, M. microti). The immunogenic composition, vaccine, or pharmaceutical composition comprises a fusion polypeptide comprising one or more M. tuberculosis starvation antigens, the fusion polypeptide units being M. tuberculosis antigens. Further, the invention relates to the use of a vaccine comprising a fusion polypeptide sequence or a nucleic acid sequence of the invention provided at the same time as BCG, mixed with BCG or administered separately at different sites or routes for the preparation of said immunogenic composition, vaccine or pharmaceutical composition.