Compositions and pharmaceutical formulations and their use in the treatment of patients with diseases of auto antibodies positive, as well as the process to assess the response to treatment

摘要

Compositions and pharmaceutical formulations and their use in the treatment of patients with diseases of auto antibodies positive, as well as the process to assess the response to treatment. The present invention relates to methods and compositions for use in the treatment of patients with the disease, auto antibody positive.In a specific way, the present invention relates to a method for treating a patient who has (a) a title of ANA 1: 80 or greater and / or greater than or equal to 30 IU / ml of anti dsDNA antibodies in blood plasma or serum comprising administering an amount therapeutically A imunomodulatu00e1rio effective agent, such as an antagonist of neutrocina alpha.In addition, it is provided a method to reduce the frequency and / or the quantity of corticosteroid administration to patients. In preferred arrangements, the patient has systemic lupus erythematosus. Methods for determining whether a patient with lupus is responding to medical treatment are also provided.