anti-obesity composition, use of melissa extract, use of a mixture of melissa extract and mori folium extract, use of a mixture of melissa extract, artemisia extract and mori folium extract and method to suppress obesity

摘要

ANTI-OBESITY COMPOSITION, USE OF MELISSA EXTRACT, USE OF A MIXTURE OF MELISSA EXTRACT AND MORI FOLIUM EXTRACT, USE OF A MIXTURE OF MELISSA EXTRACT, ARTEMISIA EXTRACT AND MORI FOLIUM EXTRACT AND METHOD TO SUPPRESS THE OBESITY The invention features an anti-obesity composition that comprises Melissa extract as an active ingredient, the use of Melissa extract, and a method for suppressing obesity using the composition. In addition, the present invention features an anti-obesity composition that comprises Melissa extract and Mori Folium extract as active ingredients, the use of a mixture of Melissa extract and Mori Folium extract, and a method for suppressing obesity using the composition. In addition, the present invention features an anti-obesity composition comprising Melissa extract, Artemisia extract and Mori Folium extract as active ingredients, the use of a mixture of Melissa extract, Artemisia extract and extract Mori Folium, and a method to suppress obesity using the composition. When the present compositions are administered to genetically obese mice or to obese mice induced by a high-fat diet, the present compositions reduce body weight, body fat and gonadic fat, and reduce the level of cholesterol in the blood and the blood glucose level related to obesity. In addition, the present compositions suppress adipocyte hypertrophy, and inhibit the accumulation of lipids in the liver by reducing the size and number of lipid vacuoles. In addition, in human clinical experimentation the present compositions show that body weight, PPCI, body fat, especially visceral fat, apolipoprotein E concentration, total cholesterol / HDL cholesterol ratio and LDL cholesterol / HDL cholesterol ratio are significantly decreased, and the atherogenic index is improved and muscle mass is increased. In this way, the present compositions can be usefully applied as an anti-obesity composition for the reduction of body weight and the suppression of abdominal fat, particularly visceral fat.