Cytotoxic Activity of Curcumin, Melissa, and Cloves Extracts on Colon, Lung, and Breast Cancer Cell Lines.

摘要

Cancer is a group of diseases characterized by abnormal cells growth and spread to other parts of the body. It is one of the most common devastating disease affecting millions of people per year. In 2012 about 14.1 million new cases of cancer occurred globally, it caused about 8.2 million deaths or 14.6% of all human deaths. Plants have proved to be an important natural source of anti-cancer therapy for several years. These anti-cancer compounds have been found to be clinically active against various types of cancer cells while the actual compounds isolated from the plant frequently may not serve as the drugs; they provide leads for the development of potential novel agents. Curcuma longa, Melissa officialis, and Syzygium aromaticum were used to in this study to determine their effects on three cancer cell lines which are colon, lung, and breast cancer. Growth analysis was determined using a cell viability indicator Alamar blue and a florescent plate reader. Methanolic leaf extracts from these three test compounds have demonstrated potential for containing novel anti-tumor compounds. Melissa officialis and Syzygium aromaticum demonstrated the most significant ability to reduce the cellular proliferation of colon cancer cell lines while breast cancer cell lines appeared to be more sensitive to Curcuma longa extracts. However, Syzygium aromaticum extract proved to be exceedingly toxic to the cellular proliferation of lung cancer cells.