(1-aza-bicyclo 3.3.1 non-4-yl) - 5- (1h-indol-5-yl) -heteroaryl -amines as n-achr cholinergic ligands for the treatment of psychotic disorders and neurodegenerative

摘要

(1 -AZA-BICYCLE [3.3.1] NON-4-IL) - [5- (1 H-INDOL-5-IL) -HETEROARYL] -AMINES AS N-ACHR CHOLINERGICAL LINKERS FOR TREATMENT OF PSYCHOTIC DISORDERS AND NEURODEGENERATI VOS. The present invention relates to compounds of formula (I) wherein: n represents 0, 1, 2, 3, 4 or 5, R independently represents hydroxyl, damage, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate, Y is one of the following groups: in the free base or acid addition salt form, the processes for their production, the pharmaceutical compositions comprising them and their use in the manufacture of a medicament for treatment. and / or delayed progression of psychotic and neurodegenerative disorders.