nucleic acid molecule, polypeptide, vector, cell, methods for the manufacture of a polypeptide, for the treatment of an animal, for the modification of antagonistic activity of a polypeptide, and for the rational design of mutations in a polypeptide, pharmaceutical composition use of polypeptide, variant polypeptide antagonist, and homodimer

摘要

NUCLEIC ACID MOLECULE, POLYPEPTIDE, VECTOR, CELL, METHODS FOR THE MANUFACTURING OF A POLYPEEPTIDE, FOR THE TREATMENT OF AN ANIMAL, FOR THE MODIFICATION OF THE ANTAGONIST ACTIVITY OF A POLYPTIDE, MUCH OF ACTIVATION, AND MUCH OF ACTIVATION USE OF POLYPEPTIDE, VARIANT POLYPEPTIDE ANTAGONIST, AND, HOMODYMER D Applicants describe a circularly exchanged growth hormone polypeptide antagonist; compositions comprising said antagonist and methods for treating conditions that would benefit from administering said antagonist.