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A drug that is a Derivative of a derivative carbostirilo Donepezil to treat Alzheimer's disease

机译:一种药物,它是一种衍生的卡波替利洛多奈哌齐的衍生物,可以治疗阿尔茨海默氏病

摘要

1. - a drug to treat Alzheimer's disease which comprises as Active Components of carbostirilo a Derivative of the General formula: Where R is a group alquileno is lower, a cycloalkyl Group, the link between the 3 and 4 positions of the Skeleton is a Single Bond carbostirilo Or a double Bond, or one of its salts; and Donepezil or one of its sales.2.- the product according to claim 1, characterized because the Derivative of carbostirilo is 6 - [4 - (1 - Cyclohexyl - 1h-tetrazol-5-yl) butoxy] - 3.4 - dihidrocarbostirilo or one of its Salts. 3. - the product according to claim 1 or 2, characterized in that the salt is Donepezil Donepezil hydrochloride. 4.- the use of carbostirilo derivative or a Salt as described in claim 1 or 2, and Donepezil or one of its Salts for the preparation of a Medicament for treating Alzheimer's disease. 5. - the use and that is claimed in claim 4, wherein the salt is Donepezil Donepezil hydrochloride. 6.A method for treating Alzheimer's disease which comprises administering an effective amount of the Derivative of carbostirilo or one of its Salts described in claim 1 or 2, and Donepezil or their salts, to a patient in need tratamiento.7. - Said the method under L In claim 6, characterized in that the salt is Donepezil Donepezil hydrochloride.
机译:1.-一种用于治疗阿尔茨海默氏病的药物,该药物包含卡波替利洛的活性成分和通式的衍生物:当R为基亚基较低的基团时,为环烷基,骨架的3和4位之间的连接为单个碳原子或双键,或其盐之一; 2.根据权利要求1所述的产品,其特征在于,所述卡波斯蒂洛的衍生物为6- [4-(1-环己基-1h-四唑-5-基)丁氧基] -3.4-二氢卡波斯蒂洛或它的盐之一。 3.根据权利要求1或2的产品,其特征在于所述盐是多奈哌齐盐酸多奈哌齐。 4.-权利要求1或2所述的卡波斯蒂罗洛衍生物或盐以及多奈哌齐或其盐之一在制备用于治疗阿尔茨海默氏病的药物中的用途。 5.权利要求4的用途,其中所述盐是多奈哌齐盐酸多奈哌齐。 6,一种治疗阿尔茨海默氏病的方法,该方法包括对有需要曲坦的患者给予有效量的权利要求1或2所述的卡斯托西罗或其盐之一和多奈哌齐或其盐。 -根据权利要求6所述的方法,其特征在于,所述盐是盐酸多奈哌齐。

著录项

  • 公开/公告号CO6251249A2

    专利类型

  • 公开/公告日2011-02-21

    原文格式PDF

  • 申请/专利号CO20090145995

  • 发明设计人 ARAI HEII;

    申请日2009-12-21

  • 分类号A61K31/445;

  • 国家 CO

  • 入库时间 2022-08-21 18:06:55

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