Vesicular stomatitis virus (VSV) and Genetically Modified attenuated and immunogenic compositions containing them.

摘要

The present Invention relates to methods for generating genetically modified strains and attenuated vesicular stomatitis virus (VSV) for use in the preparation of immunogenic compositions.More particularly, The Invention relates to the identification of specific Genetic modifications that result in an attenuated VSV virus growing Performance and an increase in the stability of attenuated Virus for the preparation of immunogenic compositions.It also describes the methods of cell culture to spread and use in large scale production of VSV.